Kambo, Sapo or Acate are just a couple of names for a traditional natural remedy that is used by various indigenous tribes of the Amazon. It consists of the skin secretions of the South American nocturnal treefrog (lat. Phyllomedusa bicolor).

Because of its potent effect on the whole human organism, the Kambo-frog treatment has been used for ages in the Amazon area. The local tribesmen traditionally use it for:

  • Healing and cleansing of the body

  • Physical strength and stamina

  • Spiritual and mental clarity

  • Luck and zest of life.



The Kambo secretion based on human use was first researched and described by western scientists John Daly, Vittorio Erspamer and their team, published in 1992.  

Vittori Erspamer already published an article based on his studies of peptides in Phyllomedusa skin “a huge factory and store-house of active peptides” in 1985.  

Those bio active peptides are also the reason why the pharma-industry is so interested in it, developing a new medication from one of the peptides could be worth hundreds of millions of dollars and there are already several patents existing on some of the peptides.  

Here are some of the peptides found in the secretion:

adenoregulins, bradykinins, tachykinins, caerulein, sauvagine, tryptophyllins, deltorphins, dermaseptins, dermorphins, phyllocaeruleın and bombesins.        

More information about the scientific research can be fund here:                                                                                                                                      

https://www.researchgate.net/publication/14933636_Pharmacological_studies_of_'sapo'_from_the_frog_Phyllomedusa_bicolor_skin_ A_drug_used_by_the_Peruvian_Matses_Indians_in_shamanic_hunting_practice 




The Kambo frog aka “Giant waxy monkey tree frog” lives in the trees and has not much to fear about natural enemies. You can hear the mating call he produces as soon as it gets dark, when imitating that sound he would respond to it, especially when raining and around the new moon, thereby it is easily to locate him. 

Often times one would need to climb  a high tree to get the frog. As the frogs do not try to escape, it is very easy to get them move on to a large wooden stick or branch from where they can be transported to the place where then the extraction will happen.



For that four wooden sticks are put into the ground shaping a small square. Then the frog gets tied with four separated strings by all of his extremities to the wooden sticks, suspending the animal in a way so that it does not move. To make the frog excrete the poison he needs to feel in danger,  thereby keeping him tied on the strings makes him to excrete a white, slimy secretion on his legs and the side of his body. This substance is scraped off with a small piece of wood and then transferred to another flat wooden stick, on which it later dries out and gets durable for a long time. The frog is not really hurt during this procedure – nevertheless, the whole act is also not comfortable for him. Once the extraction is done, the frog is released into freedom and his natural surroundings.